Wednesday July 2, 2014 |
13:45 | Opening Ceremony |
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Prof. Xavier PANNECOUCKE (INSA ROUEN, Saint Etienne du Rouvray, France) |
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Prof. Hubert VAUDRY (UNIVERSITY OF ROUEN, Mont-Saint-Aignan, France) |
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(THERMO FISHER SCIENTIFIC) |
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Mr Nicolas MAYER-ROSSIGNOL (PRÉSIDENT DU CONSEIL RÉGIONAL DE HAUTE-NORMANDIE, Rouen, France) |
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Mr Frédéric SANCHEZ (PRÉSIDENT DE LA CREA, Rouen, France) |
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Dr Pascal GEORGE (SCT & INDEPENDENT SCIENTIFIC EXPERT & ADVISER, Longvilliers, France) |
| Session 1: Ehrlich Prize
Sponsored by Janssen-Cilag |
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| Session Chair: |
Dr Jean-François BONFANTI (JANSSEN R&D, Val de Reuil, France) |
14:00 | Ehrlich Prize Winner Natural Antitumor Macrolides Acting on Tubulin: Synthesis and Functional Exploration |
Prof. Karl-Heinz ALTMANN (SCS DMCCB & SWISS FEDERAL INSTITUTE OF TECHNOLOGY, Zürich, Switzerland) |
| Session 2: Epigenetics |
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| Session Chair: |
Dr Luc VAN HIJFTE (SCT & NOVALIX, Nijmegen, The Netherlands) |
15:00 | Discovery and Optimisation of a Novel Series of EZH2 Inhibitors, Challenges and Clinical Perspectives |
Dr Jean-Christophe HARMANGE (CONSTELLATION PHARMACEUTICALS, Cambridge, United States) |
15:45 | Coffee Break and Exhibition |
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| Session 3: Stabilized Peptides
Sponsored by Ipsen |
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| Session Chair: |
Dr Olivier LAVERGNE (., Palaiseau, France) |
16:45 | 2-Clips Peptides: A Novel Class of Biopharmaceuticals |
Prof. Peter TIMMERMAN (PEPSCAN THERAPEUTICS, Lelystad, The Netherlands) |
17:30 | Design and Applications of Protein Epitope Mimetics |
Prof. John ROBINSON (UNIVERSITY OF ZÜRICH, Zürich, Switzerland) |
18:30 | Welcome Reception |
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20:30 | Public Lecture: La recherche des médicaments d’hier à aujourd’hui Open to the general public of Rouen and all symposium participants (venue: Hôtel de Région, room Hémicycle) |
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Prof. Jean COSTENTIN (UNIVERSITY OF ROUEN, Rouen, France) |
Thursday July 3, 2014 |
| Session 4: Molecular Space
Sponsored by LabEx SynOrg |
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| Session Chair: |
Prof. Xavier PANNECOUCKE (INSA ROUEN, Saint Etienne du Rouvray, France) |
08:30 | Excursions in Uncharted Structural Space |
Prof. Erick M. CARREIRA (ETH ZÜRICH, Zürich, Switzerland) |
Session 5: Short Communications
Sponsored by SCT | |
| Session Chair: |
Prof. Patrick DALLEMAGNE (UNIVERSITY OF CAEN, Caen, France) |
09:15 | Silicon-containing Tetrahydrocyclopenta[c]acridine Derivatives as CDKs Inhibitors: Design, Organometallic Synthesis, Metabolic Stability and Optimisation |
Prof. Philippe BELMONT (UNIVERSITY PARIS DESCARTES, Paris, France) |
09:45 | Combining Organic Synthesis, Software Development and Biochemistry for the Design and Discovery of Prolyl oligopeptidase Inhibitors |
Prof. Nicolas MOITESSIER (MCGILL UNIVERSITY, Montreal, Canada) |
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| Session Chair: |
Prof. Nicolas WILLAND (UNIVERSITY OF LILLE, Lille, France) |
09:15 | Identification of Cell-penetrating Compounds and their Use for Intracellular Delivery of Cathepsin D Inhibitors |
Prof. Muriel AMBLARD (CNRS-UNIVERSTY OF MONTPELLIER I, Montpellier, France) |
09:45 | Innovative Fluorescent-Based Approaches to GPCR Screening and Functional Architecture Studies |
Prof. Dominique BONNET (UNIVERSITY OF STRASBOURG, Illkirch, France) |
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10:15 | Coffee Break, Exhibition and Poster Session (odd numbers) |
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Session 7: Cardiac/Geno Safety | Session 6: Protein-protein Interactions
Sponsored by ACS |
| Session Chair: |
Prof. Gérard SIEST (UNIVERSITY OF LORRAINE & PRESIDENT OF THE EUROPEAN SOCIETY OF PHARMACOGENOMICS AND THERANOSTICS, Nancy, France) |
11:00 | Genotoxicity Screening can guide Lead Optimisation and Reduce Late Stage Attrition |
Prof. Richard WALMSLEY (UNIVERSITY OF MANCHESTER, Manchester, United Kingdom) |
11:45 | Recent Advances in Predicting Cardiac Risk during Drug Development |
Dr Arthur BROWN (CHANTEST, Cleveland, United States) |
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| Session Chair: |
Dr Gilles GUICHARD (UNIVERSITY OF BORDEAUX, CBMN, Bordeaux, France) |
11:00 | Use of Peptides to Modulate Protein-Protein Interactions |
Prof. Ernest GIRALT (INSTITUTE FOR RESEARCH IN BIOMEDICINE (IRB), Barcelona, Spain) |
11:45 | Strategies to Target Protein-Protein Interactions: from Discovery to Clinical Development |
Prof. Shaomeng WANG (UNIVERSITY OF MICHIGAN, Michigan, United States) |
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12:30 | Lunch |
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13:15 | Exhibition and Poster Session (Odd numbers) |
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14:00 | Career Session |
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Session 8: Oncology | Session 9: Biophysic tools and SPR
Sponsored by NovAliX |
| Session Chair: |
Dr Kam ZHANG (RIKEN, Yokohama, Japan) |
14:30 | Targeting BAX for Cancer Therapy: from Computer Screen to Mouse |
Dr Luciana MARINELLI (UNIVERSITY OF NAPOLI, Napoli, Italy) |
15:15 | Discovery of TAK-632: Pan-RAF Inhibitor with Potent Antitumor Activity against BRAF and NRAS Mutant Melanomas |
Dr Masanori OKANIWA (TAKEDA PHARMACEUTICAL COMPANY, Kanagawa, Japan) |
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| Session Chair: |
Dr Denis ZEYER (NOVALIX, Illkirch, France) |
14:30 | Exploiting the Information Rich Output of SPR Biosensor Technology in Drug Discovery – From Target Evaluation to Fragment and Lead |
Prof. Helena DANIELSON (UPPSALA UNIVERSITY, Uppsala, Sweden) |
15:15 | High-Throughput Chemical Microarray SPR: The Biophysical Tool for Fragment Based Screening in Drug Discovery |
Dr Thomas NEUMANN (GRAFFINITY PHARMACEUTICALS, Illkirch, France) |
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16:00 | Coffee Break and Exhibition |
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Session 10: Epigenetics
Sponsored by Inventiva | Session 11: Biophysics and Kinetics |
| Session Chair: |
Dr Alexis DENIS (GSK, Courtaboeuf, France) |
16:30 | Cell Identity Loss in Cancer: a Source of New Biomarkers and Therapeutic Targets |
Dr Saadi KHOCHBIN (JOSEPH FOURIER UNIVERSITY, Grenoble, France) |
17:15 | Chemical Probes for Epigenetics |
Dr Dafydd OWEN (PFIZER, Cambridge, United States) |
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| Session Chair: |
Dr Frank LEEMHUIS (MERCACHEM-SYNCOM, Nijmegen, The Netherlands) |
16:30 | Translational Biophysics: Using Biophysical Data in Medicinal Chemistry |
Dr Matthias FRECH (MERCK, Darmstadt, Germany) |
17:15 | Molecular Basis of Ligand Dissociation from GPCRs – a Molecular Dynamics and Mutagenesis Study on the Adenosine A2A Receptor |
Prof. Laura HEITMAN (UNIVERSITY OF LEIDEN, Leiden, The Netherlands) |
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| Session 12: Physicochemical Properties |
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| Session Chair: |
Dr Gerardo TURCATTI (ÉCOLE POLYTECHNIQUE FÉDÉRALE DE LAUSANNE, Lausanne, Switzerland) |
18:00 | Polar Units and Dipolar Interactions Modulating, Conformation, Lipophilicity, and other Physicochemical Properties |
Prof. Klaus MÜLLER (F. HOFFMANN-LA ROCHE, Switzerland) |
20:00 | Symposium Banquet |
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Friday July 4, 2014 |
| Session 13: Kinases
Sponsored by Servier |
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| Session Chair: |
Dr Arnaud LE TIRAN (INSTITUT DE RECHERCHES SERVIER, Croissy sur Seine, France) |
08:30 | The Lab Oddity Prevails - Discovery of pan-CDK Inhibitor BAY 1000394 (Roniciclib) for the Treatment of Cancer |
Dr Ulrich LÜCKING (BAYER HEALTHCARE, Basel, Switzerland) |
09:15 | The Design and Optimisation of Selective Protein Kinase C Theta Inhibitors for the Treatment of Autoimmune Diseases |
Dr Juan-Miguel JIMENEZ (VERTEX PHARMACEUTICALS, Abingdon, United Kingdom) |
10:00 | Coffee Break, Exhibition and Poster Session (Even numbers) |
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| Session 14: Non Standard Tools |
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| Session Chair: |
Dr Kenichiro KATAOKA (TEIJIN PHARMA LIMITED, Tokyo, Japan) |
10:45 | Specific Antidotes for Dabigatran: Structure-Guided Affinity Optimisation and Functional Characterisation |
Dr Herbert NAR (BOEHRINGER INGELHEIM, Biberach, Germany) |
11:30 | Pseudo-Natural Product Synthesis and Drug Applications |
Prof. Hiroaki SUGA (UNIVERSITY OF TOKYO, Tokyo, Japan) |
12:30 | Lunch |
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13:00 | Exhibition and Poster Session (Even numbers) |
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| Session 15: CNS - Psychiatry |
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| Session Chair: |
Dr Dominique LESUISSE (SCT & SANOFI, Chilly-Mazarin, France) |
14:00 | PDE10A Inhibitors as Potential Treatments for Schizophrenia |
Dr Jose Manuel BARTOLOME (JANSSEN RESEARCH & DEVELOPMENT, Toledo, Spain) |
14:45 | Novel Imidazoles as Selective TAAR1 Partial Agonists for the Treatment of Psychiatric Disorders |
Dr Giuseppe CECERE (F. HOFFMANN-LA ROCHE, Basel, Switzerland) |
| Session 16: Pierre Fabre Award for Therapeutic Innovation
Sponsored by Pierre Fabre |
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| Session Chair: |
Dr PHILIPPE MAILLOS (INSTITUT DE RECHERCHE PIERRE FABRE, CASTRES, France) |
15:30 | Pierre Fabre Lecture |
Prof. Sebastien PAPOT (UNIVERSITY OF POITIERS, Poitiers, France) |
| Session 17: Closing |
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| Session Chair: |
Prof. Janos SAPI (SCT & UNIVERSITY OF REIMS-CHAMPAGNE-ARDENNE, Reims, France) |
16:15 | Prizes and Closing Remarks |
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| Session Chair: |
Dr Christine CONTINO-PEPIN (UNIVERSITY OF AVIGNON, Avignon, France) |
16:25 | RICT 2015 |
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16:30 | End of the Symposium |
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